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Therapies enhancing GSH could become a cornerstone to reduce severity and fatal outcomes of inflammatory diseases and COVID-19 and increasing GSH levels may prevent and subdue these diseases

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Glutathione also plays a central role in the liver

Future Direction and Call to Action The current evidence gap presents an opportunity for orthopaedic investigators to establish high-quality prospective registries evaluating peptide exposure in real-world musculoskeletal populations

The evidence is mechanistically consistent and promising, but has not reached the level required for FDA approval or clinical guideline inclusion